Evaluation of Copeptin as a novel marker for predicting the prognosis of fatty liver disease and its complications in obesity

Authors

Abeer Cheaid Yousif Al-Fatlawi, Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, IraqFollow
Ameer Nazim Kamel, Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq
Bashir Ghafel Hwan, Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq
Alwan Karem Alwan, Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq
Muhammad hamed Jasim, Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq

Abstract

Objectives: Copeptin is an independent, persistent plasma marker for vasopressin (VP) linked to all aspects of the metabolic syndrome and overweight. The study aimed to evaluate copeptin levels as a surrogate marker for predicting liver disorders in obese patients. Methods: cross sectional study include 20 obese males with mean of age (42.50± 3.17) years and 20 obese females with mean of ages (44.55±2.82) years, the plasma copeptin level was masured and related with fatty liver disease according to a validated liver enzyme, lipid profile, BMI and abdominal ultrasound. Results: Highly significant increase liver enzyme, lipid profile and BMI in both males and females obese fatty liver patients, significant elevated Copeptin concentration in both gender (13.84±0.27), (13.88±0.40) and highly significant positive correlated with ferritin, BMI and TC, (r=0.651, 0.496, 0.491 and 0.457), while showed Copeptin significant negative correlated with HDL (-0.508, -0.490). Conclusions: obese individuals with the fatty liver disease showed associated with highly increased plasma copeptin, also this marker considers a useful tool for the diagnostic pathway to risk factors of metabolic disease such as diabetes mellitus although this hypothesis needs further studies to be confirmed.

Recommended Citation

Al-Fatlawi, Abeer Cheaid Yousif; Kamel, Ameer Nazim; Hwan, Bashir Ghafel; Alwan, Alwan Karem; and Jasim, Muhammad hamed (2023) "Evaluation of Copeptin as a novel marker for predicting the prognosis of fatty liver disease and its complications in obesity," Al-Ameed Journal for Medical Research and Health Sciences: Vol. 1 : Iss. 2 , Article 5.
Available at: https://doi.org/10.61631/3005-3188.1009