Author ORCID Identifier
Tareq Maqlam
ORCID: 0009-0007-4272-4620
Abdullah H Maad
ORCID: 0000-0002-6009-5166
Abstract
Background: Preformulation studies have a significant role in anticipating formulation problems and identifying logical paths in dosage form technology.
Aim: This study aimed to evaluate the preformulation criteria of the aquatic ethanol extract of Kigelia africana fruit as topical antibacterial therapy.
Methods: The preformulation parameters of the extract were evaluated by testing its organoleptic characteristics, melting point, pH, spectroscopic assay, stability, solubility, and partition coefficient.
Results: The study demonstrated that the extract possessed satisfactory organoleptic properties, a melting point of 195.3–198.0 °C, a pH of 6.26, chemical stability under acidic conditions, photostability, higher solubility in basic conditions and in the presence of cosolvents, and a partition coefficient of 9.98.
Conclusion: The present study concludes that the aquatic ethanol extract of Kigelia africana fruit is a suitable extract for formulation as a topical preparation.
Recommended Citation
Maqlam, Tareq; Maad, Abdullah H; Shayoub, Mohammed E; and Osman, Zuheir
(2024)
"Preformulation Study of Kigelia africana Fruit Ethanolic Extract as Topical Preparations,"
Al-Ameed Journal for Medical Research and Health Sciences: Vol. 2
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.61631/3005-3188.1016