The Association Between Ferritin Marker and Iron Deficiency Anemia in Peptic Ulcer Disease Patients: A Case-Control Approach

Authors

• Sajjad Fadhil K. Abbas, Department of pathological analysis, College of Applied Medical Sciences, University of Kerbala, Kerbala, IraqFollow
• Abeer Cheaid Yousif Al-Fatlawi, Department of pathological analysis, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq
• Ahmed Hashim Abbas Al-Janabi, GIT Centre, Kerbala Health Directorate, Kerbala, Iraq

Abstract

Background: Peptic ulcer disease refers to deep erosions in the mucosal layer of the GIT and is highly associated with upper gut bleeding, which results in anaemia. Ferritin is a protein that stores iron in the body.

Aim: To estimate serum ferritin levels in relation to anaemia in peptic ulcer disease and assess its potential as a predictor of peptic ulcer bleeding.

Method: A case-control study in Kerbala, Iraq, measured ferritin by ELISA and anaemia by Hb levels on CBC, with ROC curves used to assess sensitivity and specificity.

Results: results show a significant difference in haemoglobin and ferritin levels between patients and controls. Patients have significantly lower Hb and ferritin levels than controls. Moreover, ROC curve results for ferritin were as follows: AUC: 0.827; Sensitivity: 84%; Specificity: 76%; Accuracy: 80%.

Conclusion: This study shows a strong association between low serum ferritin and bleeding peptic ulcers, suggesting that ferritin is a predictive biomarker for anaemia associated with peptic ulcer bleeding.

Recommended Citation

Abbas, Sajjad Fadhil K.; Al-Fatlawi, Abeer Cheaid Yousif; and Al-Janabi, Ahmed Hashim Abbas () "The Association Between Ferritin Marker and Iron Deficiency Anemia in Peptic Ulcer Disease Patients: A Case-Control Approach," Al-Ameed Journal for Medical Research and Health Sciences: Vol. 4 : Iss. 1 , Article 1.
Available at: https://doi.org/10.61631/3005-3188.1037